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#Beam breaks actimeter trial
Messina M, Ho S, Alekel DL (2004) Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data. Havsteen BH (2002) The biochemistry and medical significance of the flavonoids.
Harborne JB, Williams CA (2000) Advances in flavonoid research since 1992. These results suggest that flavonoid glycosides have the potential to exert a range of CNS-mediated biological activities. Hence, naringin (30 mg/kg) and gossypin (30 mg/kg) induce both anxiolytic and sedative effects. Higher doses of these two flavonoids showed a dramatic increase in the open arm exploration accompanied by a decrease in locomotor activity.
Gossypin and naringin both shared a similar profile, with low doses (1 mg/kg) inducing a robust anxiolytic effect which diminished with increasing doses of the flavonoids. However, higher doses showed possible sedative and myorelaxation effects. Myricitrin (1 mg/kg) was effective on the EPM showing a clear anxiolytic effect with no signs of sedation.
#Beam breaks actimeter plus
This study assessed the potential anxiolytic effect of three flavonoid glycosides, myrcitrin, naringin and gossypin, in the elevated plus maze test (EPM). Flavonoid glycosides, the main class of flavonoids, have been shown to exert CNS-mediated activities, particularly as sedative-hypnotics, analgesics or both, nevertheless no studies have evaluated these agents in anxiety. The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been epidemiologically associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases.
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